Home » Research Area » Respiratory Disease Research » 7-TM Receptors » Peptide Receptors » NPY Receptors » BIBO 3304 trifluoroacetate

BIBO 3304 trifluoroacetate

Cat. No. 2412

Price and Availability

For BIBO 3304 trifluoroacetate pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamide ditrifluoroacetate

Biological Activity

High affinity NPY Y₁ receptor antagonist (IC₅₀ values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y₂, Y₄ and Y₅ receptors. Inhibits NPY- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY.

Technical Data

M.Wt:

757.69

Formula:

C₂₉H₃₅N₇O₃.2CF₃CO₂H

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

191868-14-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Wieland et al (1998) Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br.J.Pharmacol. 125 549. PMID: 9806339.

Sajdyk et al (1999) Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test. Eur.J.Pharmacol. 368 143. PMID: 10193650.

Lecklin et al (2002) Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea-pig. Br.J.Pharmacol. 135 2029. PMID: 11959807.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

NPY Receptors

Peptide Receptors

Keywords: BIBO 3304 trifluoroacetate, supplier, selective, NPY, Y1, receptor, antagonists, Neuropeptide, Y, Receptors, BIBO3304, trifluoroacetate, neuropeptides

Quick Order

Find multiple products by catalog number

Appetite Modulation

Written by Sonia A. Tucci, Lynsay Kobelis & Tim Kirkham. Request a copy or view PDF today.

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

'Regulation of Vascular Reactivity by G-protein-coupled Receptors' summarizes the key GPCRs regulating vascular reactivity.

7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy