Home » Research Area » Respiratory Disease Research » 7-TM Receptors » GABA_B Receptors » Zonisamide

Zonisamide

Cat. No. 2625

Price and Availability

For Zonisamide pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: AD 810, CI 912

Chemical Name: 1,2-Benzisoxazole-3-methanesulfonamide

Biological Activity

Antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na⁺ and T-type Ca²⁺ channels, stimulates BK_Ca channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.

Technical Data

M.Wt:

212.22

Formula:

C₈H₈N₂O₃S

Solubility:

Soluble to 10 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

68291-97-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Tokumaru et al (2000) In vivo evaluation of hippocampal anti-oxidant ability of zonisamide in rats. Neurochem.Res. 25 1107. PMID: 11055748.

Sobieszek et al (2003) Zonisamide: a new antiepileptic drug. Pol.J.Pharmacol. 55 683. PMID: 14704463.

Gluck et al (2004) Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. J.Neural Transm. 111 713. PMID: 15168218.

Huang et al (2007) Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells. J.Pharmacol.Exp.Ther. 321 98. PMID: 17255467.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

GABA_A and GABA_C Receptors GABA_B Receptors Glutamate (Ionotropic) Receptors Glutamate (Metabotropic) Receptors

Miscellaneous GABA Miscellaneous Glutamate Miscellaneous Glutamate Other Channel Modulators

Keywords: Zonisamide, supplier, AD810, CI912, Antiepileptic, broad, spectrum, anticonvulsant, blocks, blockers, voltage-sensitive, Na+, sodium, T-type, Ca2+, calcium, channels, stimulates, stimulators, BKCa, calcium-activated, potassium, GABA, glutamate, monoamine, neurotransmission, inhibits, inhibitors, lipid, peroxidation, scavenges, hydroxyl, nitric, oxide, free, radicals, scavenger

Quick Order

Find multiple products by catalog number

Pain Research Guide

Reserve your free copy

Highlights over 280 products for Pain research. Reserve copy

GABA Review

Written by Ian Martin, Norman Bowery & Susan Dunn. Request a copy or view PDF today.

7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development.