R&D Systems Inc. Tocris Bioscience Boston Biochem

AG 879

Cat. No. 2617

AG 879 C18H24N2OS [148741-30-4]

Price and Availability

For AG 879 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Tyrphostin AG 879

Chemical Name: (2E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide

Biological Activity

Inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. Decreases cellular proliferation in human muscular sarcoma cell lines. Also inhibits ErbB2 and VEGFR-2 (IC50 values are approximately 1 μM for both).

Technical Data

M.Wt:
316.46
Formula:
C18H24N2OS
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
148741-30-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

He et al (2004) The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation. Cancer Biol.Ther. 3 96. PMID: 14726663.

Rende et al (2006) Role of nerve growth factor and its receptors in non-nervous cancer growth: efficacy of a tyrosine kinase inhibitor (AG879) and neutralizing antibodies antityrosine kinase receptor A and antinerve growth factor: an in-vitro and in-vivo study. Anticancer Drugs 17 929. PMID: 16940803.

If you know of a relevant citation for this product please let us know.

Keywords: AG 879, supplier, AG879, tyrosine, kinase, inhibitors, ErbB2, VEGFR-2, EGFR, Flk-1, nerve, growth, factors, inhibits, NGF, TrkA

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Some of the most potent
kinase inhibitors all on one plate

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance.

divider line

New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

divider line

Bio-Techne Events

Annual Meeting of the Japan Neuroscience Society

Annual Meeting of the Japan Neuroscience Society

September 11 - 13, 2014

Yokohama, Japan