Cat. No. 2617
Alternative Name: Tyrphostin AG 879
Chemical Name: (2E)-3-[3,5-Bis(1,1-dimethylethyl)-
Biological ActivityInhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. Decreases cellular proliferation in human muscular sarcoma cell lines. Also inhibits ErbB2 and VEGFR-2 (IC50 values are approximately 1 μM for both).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
He et al (2004) The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation. Cancer Biol.Ther. 3 96. PMID: 14726663.
Rende et al (2006) Role of nerve growth factor and its receptors in non-nervous cancer growth: efficacy of a tyrosine kinase inhibitor (AG879) and neutralizing antibodies antityrosine kinase receptor A and antinerve growth factor: an in-vitro and in-vivo study. Anticancer Drugs 17 929. PMID: 16940803.
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Keywords: AG 879, supplier, AG879, tyrosine, kinase, inhibitors, ErbB2, VEGFR-2, EGFR, Flk-1, nerve, growth, factors, inhibits, NGF, TrkA, Tocris Bioscience, EGFR Inhibitors
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