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IMD 0354

Cat. No. 2611

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Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide

Biological Activity

Inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G₀/G₁ cell cycle arrest and apoptosis in HMC-1�and breast cancer cells.

Technical Data

M.Wt:

383.67

Formula:

C₁₅H₈ClF₆NO₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

978-62-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Onai et al (2004) Inhibition of IκB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Res. 63 51. PMID: 15194461.

Tanaka et al (2005) A novel NF-κB inhibitor, IMD-0354, supresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Hematopoiesis 105 2324.

Tanaka et al (2006) A new IκB kinase β inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition. Cancer Res. 66 419. PMID: 16397257.

If you know of a relevant citation for this product please let us know.

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