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MRS 1706Cat. No. 1584 |
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Chemical Name: N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide |
Biological Activity
Potent and selective adenosine A2B receptor inverse agonist (Ki values are 1.39, 157, 112 and 230 nM for human A2B, A1, A2A and A3 receptors respectively).Licensing Information
Manufactured and sold under license from Adenosine Therapeutics, LLCCertificate of Analysis / Safety Data Sheet
References
Kim et al (2000) Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors. J.Med.Chem. 43 1165. PMID: 10737749.
Kiec-Kononowicz et al (2001) New developments in A1 and A2 adenosine receptor antagonists. Pure Appl.Chem. 73 1411.
Li et al (2007) ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. J.Pharmacol.Exp.Ther. 320 637. PMID: 17077318.
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Keywords: MRS 1706, supplier, Potent, selective, A2B, inverse, agonists, Receptors, adenosines, MRS1706
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