R&D Systems Inc. Tocris Bioscience Boston Biochem

Purvalanol B

Cat. No. 1581

Purvalanol B C20H25ClN6O3 [212844-54-7]

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Alternative Name: NG 95

Chemical Name: (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

Biological Activity

Cyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC50 > 10,000 nM). Shown to have antiproliferative properties, mediated by p42/p44 MAPK.

Licensing Information

Sold under license from the Regents of the University of California

Technical Data

M.Wt:
432.91
Formula:
C20H25ClN6O3
Solubility:
Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
212844-54-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Gray et al (1998) Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281 533. PMID: 9677190.

Gray et al (1999) ATP-site directed inhibitors of cyclin-dependent kinases. Curr.Med.Chem. 6 859. PMID: 10495356.

Knockaert et al (2002) p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene 21 6413. PMID: 12226745.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Purvalanol B, supplier, Cyclin-dependent, protein, kinases, inhibitors, Cdk, PurvalanolB, NG95

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