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(-)-Cannabidiol

Cat No. 1570

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Alternative Name: CBD

Chemical Name: 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1- yl]-5-pentyl-1,3-benzenediol

Biological Activity

Non-psychotropic constituent of cannabis that is anticonvulsive, antihyperalgesic and neuroprotective in vivo. GPR55 and weak CB₁ antagonist (IC₅₀ values are 0.445 and 3.35 μM), CB₂ receptor inverse agonist and inhibitor of anandamide uptake (IC₅₀ = 27.5 μM). Also a weak agonist at VR1 vanilloid receptors (EC₅₀ = 3.5 μM).

Technical Data

M.Wt:

314.47

Formula:

C₂₁H₃₀O₂

Solubility:

Soluble to 75 mM in ethanol and to 75 mM in DMSO

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

[13956-29-1]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

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Material Safety Data Sheet: View current batch

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References

Petitet et al (1998) Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of D⁹-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life Sci. 63 PL1. Costa et al (2004) Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation. Br.J.Pharmacol. 143 247. Thomas et al (2007) Cannabidiol displays unexpectedly high potency as an antagonist of CB₁ and CB₂ receptor agonists in vitro. Br.J.Pharmacol. 150 613. Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092.

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Keywords: (-)-Cannabidiol, Natural, cannabinoids, AMT, inhibitors, GPR55, antagonists, weak, CB1, CB2, inverse, agonists, Anandamide, Transporters, cannabinoids, Monoamine, Neurotransmitter, Non-Selective, cannabinoids, Receptors, cb2r, cb1r

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