R&D Systems Inc. Tocris Bioscience Boston Biochem

STO-609 acetate

Cat. No. 1551

STO-609 acetate C19H10N2O3.C2H4O2 [1173022-21-3]

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Chemical Name: 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate

Biological Activity

Selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively); competes for the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK.

Technical Data

M.Wt:
374.35
Formula:
C19H10N2O3.C2H4O2
Solubility:
Soluble to 45 mM in 100mM NaOH and to 10 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1173022-21-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Tokumitsu et al (2002) STO-609, a specific inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase. J.Biol.Chem. 277 15813. PMID: 11867640.

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Keywords: STO-609 acetate, supplier, Selective, CaM, kinases, inhibitors, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, Calmodulin-Activated

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