STO-609 acetate

Cat. No. 1551

STO-609 acetate C19H10N2O3.C2H4O2 [1173022-21-3]

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Chemical Name: 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate

Biological Activity

Selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively); competes for the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK.

Technical Data

Soluble to 45 mM in 100mM NaOH and to 10 mM in DMSO with sonication
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Tokumitsu et al (2002) STO-609, a specific inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase. J.Biol.Chem. 277 15813. PMID: 11867640.

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Keywords: STO-609 acetate, supplier, Selective, CaM, kinases, inhibitors, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, Calmodulin-Activated, Calcium Binding Protein Modulator Inhibitors

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