Cat. No. 1550
Chemical Name: 5-(4-Chlorophenyl)-1-(4-methoxyphen
Biological ActivityHighly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo. Orally active.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Smith et al (1998) Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A 95 13313. PMID: 9789085.
Daikoku et al (2005) Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res. 65 3735. PMID: 15867369.
Takeuchi et al (2005) COX inhibition and NSAID-induced gastric damage - roles in various pathogenic events. Curr.Top.Med.Chem. 5 475. PMID: 15974942.
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Keywords: SC 560, supplier, Cyclooxygenase, COX-1, inhibitors, Oxygenases, Oxidases, SC560
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April 12 - 15, 2015