R&D Systems Inc. Tocris Bioscience Boston Biochem

SC 560

Cat. No. 1550

SC 560 C17H12ClF3N2O [188817-13-2]

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Chemical Name: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole

Biological Activity

Highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo. Orally active.

Technical Data

M.Wt:
352.74
Formula:
C17H12ClF3N2O
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
188817-13-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Smith et al (1998) Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A 95 13313. PMID: 9789085.

Daikoku et al (2005) Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res. 65 3735. PMID: 15867369.

Takeuchi et al (2005) COX inhibition and NSAID-induced gastric damage - roles in various pathogenic events. Curr.Top.Med.Chem. 5 475. PMID: 15974942.

If you know of a relevant citation for this product please let us know.

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Keywords: SC 560, supplier, Cyclooxygenase, COX-1, inhibitors, Oxygenases, Oxidases, SC560

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