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SC 560Cat. No. 1550 |
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Chemical Name: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole |
Biological Activity
Highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo. Orally active.Certificate of Analysis / Safety Data Sheet
References
Smith et al (1998) Pharmacological analysis of cyclooxygenase-1 in inflammation. Pharmacology 95 13313.
Daikoku et al (2005) Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res. 65 3735. PMID: 15867369.
Takeuchi et al (2005) COX inhibition and NSAID-induced gastric damage - roles in various pathogenic events. Curr.Top.Med.Chem. 5 475. PMID: 15974942.
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Keywords: SC 560, supplier, Cyclooxygenase, COX-1, inhibitors, Oxygenases, Oxidases, SC560
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