R&D Systems Inc. Tocris Bioscience Boston Biochem

NSC 95397

Cat. No. 1547

NSC 95397 C14H14O4S2 [93718-83-3]

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Chemical Name: 2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone

Biological Activity

Potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (Ki values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125 - 180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G2/M phase transition in vitro.

Technical Data

M.Wt:
310.38
Formula:
C14H14O4S2
Solubility:
Soluble to 50 mM in DMSO and to 5 mM in ethanol
Purity:
>97 %
Storage:
Desiccate at -20°C
CAS No:
93718-83-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Lazo et al (2002) Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Mol.Pharmacol. 61 720. PMID: 11901209.

Han et al (2004) NAD(P)H:Quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors. J.Pharmacol.Exp.Ther. 309 64. PMID: 14718602.

Melchheier et al (2005) Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation. Biochem.Biophys.Res.Commun. 327 1016. PMID: 15652497.

If you know of a relevant citation for this product please let us know.

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Keywords: NSC 95397, supplier, Selective, Cdc25, dual, specificity, phosphatases, inhibitors, NSC95397

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