Cat. No. 1547
Chemical Name: 2,3-bis[(2-Hydroxyethyl)thiol]-1,4-
Biological ActivityPotent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (Ki values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125 - 180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G2/M phase transition in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Certificate of Analysis / Safety Data Sheet
Lazo et al (2002) Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Mol.Pharmacol. 61 720. PMID: 11901209.
Han et al (2004) NAD(P)H:Quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors. J.Pharmacol.Exp.Ther. 309 64. PMID: 14718602.
Melchheier et al (2005) Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation. Biochem.Biophys.Res.Commun. 327 1016. PMID: 15652497.
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Keywords: NSC 95397, supplier, Selective, Cdc25, dual, specificity, phosphatases, inhibitors, NSC95397