R&D Systems Inc. Tocris Bioscience Boston Biochem

NSC 95397

Cat. No. 1547

NSC 95397 C14H14O4S2 [93718-83-3]

Price and Availability

For NSC 95397 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone

Biological Activity

Potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (Ki values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125 - 180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G2/M phase transition in vitro.

Technical Data

M.Wt:
310.38
Formula:
C14H14O4S2
Solubility:
Soluble to 50 mM in DMSO and to 5 mM in ethanol
Purity:
>97 %
Storage:
Desiccate at -20°C
CAS No:
93718-83-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Lazo et al (2002) Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Mol.Pharmacol. 61 720. PMID: 11901209.

Han et al (2004) NAD(P)H:Quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors. J.Pharmacol.Exp.Ther. 309 64. PMID: 14718602.

Melchheier et al (2005) Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation. Biochem.Biophys.Res.Commun. 327 1016. PMID: 15652497.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: NSC 95397, supplier, Selective, Cdc25, dual, specificity, phosphatases, inhibitors, NSC95397

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Checkpoint Kinases & the DNA Damage Response

Written by Michelle D. Garrett and Ian Collins

Cell Cycle Kinases Poster

A summary of the response of the checkpoint kinase signaling network to DNA damage, including activation of DNA repair, cell-cycle arrest, senescence and apoptosis.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

Tocris Events

ICE/ENDO 2014

ICE/ENDO 2014

June 21 - 23, 2014

Chicago, USA