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(S)-CPW 399

Cat. No. 1543

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Chemical Name: (S)-α-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoic acid

Biological Activity

Novel subtype-selective and weakly desensitizing AMPA receptor partial agonist (K_i values are 44, 109, 223, 1890 and 2090 nM at GluR5, GluR1, GluR2, GluR3 and GluR4 receptors respectively). Exhibits potent agonist activity at GluR1 and GluR2 subunit-containing AMPA receptors (EC₅₀ values are 24.9 and 13.9 μM respectively) and is excitotoxic in vitro.

Technical Data

M.Wt:

239.23

Formula:

C₁₀H₁₃N₃O₄

Solubility:

Soluble to 50 mM in water

Purity:

>98 %

Storage:

Desiccate at -20°C

CAS No:

389888-02-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Campiani et al (2001) Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent and subtype-selective AMPA receptor full agonist with partial desensitization properties. J.Med.Chem. 44 4501. PMID: 11741469.

Sinclair et al (2003) Inherent desensitisation-preventing properties of a novel subtype-selective AMPA receptor agonist, (S)-CPW 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells. Neurochem.Int. 42 499. PMID: 12547649.

Butini et al (2008) 1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptor ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators. J.Med.Chem. 51 6614. PMID: 18811139.

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Keywords: (S)-CPW 399, supplier, Subtype-selective, weakly, desensitizing, AMPA, agonists, Glutamate, Receptors, iGlur, Ionotropic, (S)-CPW399

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