R&D Systems Inc. Tocris Bioscience Boston Biochem

Splitomicin

Cat. No. 1542

Splitomicin C13H10O2 [5690-03-9]

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Chemical Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Biological Activity

Inhibitor of Sir2p (IC50 = 60 μM), an NAD+-dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.

Technical Data

M.Wt:
198.22
Formula:
C13H10O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
5690-03-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Bedalov et al (2001) Identification of a small molecule inhibitor of Sir2p. Proc.Natl.Acad.Sci.U.S.A. 98 15113. PMID: 11752457.

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View Related Products by Target

Keywords: Splitomicin, supplier, Sir2p, inhibitors, Sirtuin, Sir2-like, Family, Deacetylases

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