Cat. No. 1542

Splitomicin C13H10O2 [5690-03-9]

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Chemical Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Biological Activity

Inhibitor of Sir2p (IC50 = 60 μM), an NAD+-dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Bedalov et al (2001) Identification of a small molecule inhibitor of Sir2p. Proc.Natl.Acad.Sci.U.S.A. 98 15113. PMID: 11752457.

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Keywords: Splitomicin, supplier, Sir2p, inhibitors, Sirtuin, Sir2-like, Family, Deacetylases, Sir 2-like Family Deacetylase Inhibitors

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