R&D Systems Inc. Tocris Bioscience Boston Biochem

Miglitol

Cat. No. 4985

Miglitol C8H17NO5 [72432-03-2]

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Alternative Name: Bay m1009

Chemical Name: (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(2-hydroxymethyl)-3,4,5-piperidinetriol

Biological Activity

Inhibitor of α-glucosidase; antihyperglycemic. Suppresses postprandial hyperglycemia in vivo and reduces plasma glucose concentration in normal rats and in several animal models of diabetes. Shown to inhibit the loss of pancreatic β cells in type 2 diabetic rats. Also inhibits apoptosis and mitochondrial overproduction of reactive oxygen species in endothelial cells in vitro.

Technical Data

M.Wt:
207.22
Formula:
C8H17NO5
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
72432-03-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Sels et al (1999) Miglitol, a new α-glucosidase inhibitor. Expert.Opin.Pharmacother. 1 149. PMID: 11249557.

Goda et al (2007) Effects of miglitol, an α-glucosidase inhibitor, on glycaemic staus and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats. Br.J.Nutr. 98 702. PMID: 17537288.

Aoki et al (2012) Miglitol, an anti-diabetic drug, inhibits oxdiative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. J.Pharmacol.Sci. 120 121. PMID: 23018899.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Miglitol, supplier, Baym1009, antidiabetic, alpha, a, α-glucosidase, inhibitor, inhibits

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