Miglitol

Cat. No. 4985

Miglitol C8H17NO5 [72432-03-2]

Price and Availability

For Miglitol pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Bay m1009

Chemical Name: (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(2-hydroxymethyl)-3,4,5-piperidinetriol

Biological Activity

Inhibitor of α-glucosidase; antihyperglycemic. Suppresses postprandial hyperglycemia in vivo and reduces plasma glucose concentration in normal rats and in several animal models of diabetes. Shown to inhibit the loss of pancreatic β cells in type 2 diabetic rats. Also inhibits apoptosis and mitochondrial overproduction of reactive oxygen species in endothelial cells in vitro.

Technical Data

M.Wt:
207.22
Formula:
C8H17NO5
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
72432-03-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Sels et al (1999) Miglitol, a new α-glucosidase inhibitor. Expert.Opin.Pharmacother. 1 149. PMID: 11249557.

Goda et al (2007) Effects of miglitol, an α-glucosidase inhibitor, on glycaemic staus and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats. Br.J.Nutr. 98 702. PMID: 17537288.

Aoki et al (2012) Miglitol, an anti-diabetic drug, inhibits oxdiative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. J.Pharmacol.Sci. 120 121. PMID: 23018899.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Miglitol, supplier, Baym1009, antidiabetic, alpha, a, α-glucosidase, inhibitor, inhibits

Quick Order

Find multiple products by catalog number

divider line

New Product E-alerts

Sign up for email updates from Tocris

e-alerts

Enter your email address below to sign up to receive our email updates:

divider line

Bio-Techne Events

FEBS 2015

40th FEBS Congress: The Biochemical Basis of Life

July 4 - 9, 2015

Berlin, Germany