Clozapine N-oxide

Cat. No. 4936

Clozapine N-oxide C18H19ClN4O [34233-69-7]

Price and Availability

For Clozapine N-oxide pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Biological Activity

Metabolite of clozapine (Cat. No. 0444). Activates human muscarinic designer receptors (DREADDs). Silences hippocampal neurons expressing hM4 DREADDs in vitro. Suppresses food intake in hyperphagic mice with hM3Dq-expressing, LMO4-deficient, paraventricular hypothalamic neurons.

Technical Data

Soluble to 100 mM in water and to 50 mM in DMSO
>98 %
Store at RT


Other Information

  • This product contains 1 molar equivalent of ethanol.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet


Eiermann et al (1997) The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. Br.J.Clin.Pharmacol. 44 439. PMID: 9384460.

Armbruster et al (2007) Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc.Natl.Acad.Sci.U.S.A. 104 5163. PMID: 17360345.

Zaman et al (2014) LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia. J.Neurosci. 34 140. PMID: 24381275.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: Clozapine N-oxide, supplier, clozapine, metabolite, 5HT2A/2C, non-selective, receptors, serotonin, 5HT2C, 5HT2, 5HT2A, dopaminergic, dopamine, antagonists, D4, clozapine-N-oxide, DREADDs, muscarnic, receptors, designer, receptors, DREADD Activators

Quick Order

Find multiple products by catalog number

divider line

New Product Guide


Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area

N-Acetylcysteine amide

Glutathione (GSH) precursor; neuroprotective

Salvinorin B

Activates the κ-opioid DREADD receptor (KORD)

DREADD agonist 21

Potent muscarinic hM3Dq DREADD receptor agonist


HIV cell entry blocker

Carbenicillin disodium salt

Antibiotic; selection reagent for AMPR transformed cells

Kanamycin sulfate

Broad spectrum antibiotic

Vancomycin HCl


Ampicillin sodium salt

Antibiotic; selection reagent

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Pharmacology 2015

Pharmacology 2015

December 15 - 17, 2015

London UK