Cat. No. 4936
Chemical Name: 8-Chloro-11-(4-methyl-4-oxido-1-pip
Biological ActivityMetabolite of clozapine (Cat. No. 0444). Activates human muscarinic designer receptors (DREADDs). Silences hippocampal neurons expressing hM4 DREADDs in vitro. Suppresses food intake in hyperphagic mice with hM3Dq-expressing, LMO4-deficient, paraventricular hypothalamic neurons.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Eiermann et al (1997) The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. Br.J.Clin.Pharmacol. 44 439. PMID: 9384460.
Armbruster et al (2007) Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc.Natl.Acad.Sci.U.S.A. 104 5163. PMID: 17360345.
Zaman et al (2014) LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia. J.Neurosci. 34 140. PMID: 24381275.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Clozapine N-oxide, supplier, clozapine, metabolite, 5HT2A/2C, non-selective, receptors, serotonin, 5HT2C, 5HT2, 5HT2A, dopaminergic, dopamine, antagonists, D4, clozapine-N-oxide, DREADDs, muscarnic, receptors, designer, receptors, Tocris Bioscience, DREADD Activators
Find multiple products by catalog number
New Products in this Area
Potent and selective hM3Dq DREADD agonistN-Acetylcysteine amide
Glutathione (GSH) precursor; neuroprotectiveSalvinorin B
Activates the κ-opioid DREADD (KORD)DREADD agonist 21
Potent hM3Dq DREADD agonist18A
HIV cell entry blocker
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for AAI 2016.