Cat. No. 4877
Chemical Name: 6-(1,1-Dimethylethyl)-2-[(2-furanyl
Biological ActivityCalcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 μM, in TMEM16A-expressing FRT cells).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
De La Fuente et al (2008) Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol.Pharmacol. 73 758. PMID: 18083779.
Namkung et al (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 286 2365. PMID: 21084298.
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Keywords: CaCCinh-A01, supplier, calcium-activated, chloride, channels, CaCC, inhibitors, inhibits, TMEM16A, Tocris Bioscience, Chloride Channel Blockers
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March 19 - 23, 2016
Denver, CO, USA