R&D Systems Inc. Tocris Bioscience Boston Biochem

CaCCinh-A01

Cat. No. 4877

CaCCinh-A01 C18H21NO4S [407587-33-1]

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Chemical Name: 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

Biological Activity

Calcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 μM, in TMEM16A-expressing FRT cells).

Technical Data

M.Wt:
347.43
Formula:
C18H21NO4S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
407587-33-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

De La Fuente et al (2008) Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol.Pharmacol. 73 758. PMID: 18083779.

Namkung et al (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 286 2365. PMID: 21084298.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: CaCCinh-A01, supplier, calcium-activated, chloride, channels, CaCC, inhibitors, inhibits, TMEM16A

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