Cat. No. 4801
Chemical Name: 4-[6-Methoxy-2-[(1E)-2-(3-nitrophen
Biological ActivityNR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). Requires binding of glutamate to the GluN2 subunit.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Mosley et al (2010) Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J.Med.Chem. 53 5476. PMID: 20684595.
Hansen and Traynelis (2011) Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J.Neurosci. 31 3650. PMID: 21389220.
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Keywords: QNZ 46, supplier, QNZ46, Glu, NR2C, NR2D, antagonists, glutamate, NMDA, receptors