Cat. No. 4801
Chemical Name: 4-[6-Methoxy-2-[(1E)-2-(3-nitrophen
Biological ActivityNR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). Requires binding of glutamate to the GluN2 subunit.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Mosley et al (2010) Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J.Med.Chem. 53 5476. PMID: 20684595.
Hansen and Traynelis (2011) Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J.Neurosci. 31 3650. PMID: 21389220.
If you know of a relevant citation for this product please let us know.
Keywords: QNZ 46, supplier, QNZ46, Glu, NR2C, NR2D, antagonists, glutamate, NMDA, receptors
Find multiple products by catalog number
New Products in this Area
AMPAkine; positive allosteric modulator of AMPAPregnenolone sulfate sodium salt
NMDA PotentiatorLY 404187
Selective AMPA receptor positive allosteric modulator
May 19 - 22, 2015