R&D Systems Inc. Tocris Bioscience Boston Biochem

QNZ 46

Cat. No. 4801

QNZ 46 C24H17N3O6 [1237744-13-6]

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Chemical Name: 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoic acid

Biological Activity

NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). Requires binding of glutamate to the GluN2 subunit.

Technical Data

M.Wt:
443.41
Formula:
C24H17N3O6
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at RT
CAS No:
1237744-13-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Mosley et al (2010) Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J.Med.Chem. 53 5476. PMID: 20684595.

Hansen and Traynelis (2011) Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J.Neurosci. 31 3650. PMID: 21389220.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: QNZ 46, supplier, QNZ46, Glu, NR2C, NR2D, antagonists, glutamate, NMDA, receptors

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