Cat. No. 4736
Chemical Name: N,N'-1,8-Octanediylbis(2,2-dichloroa
Biological ActivityInhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC50 = 0.3 μM). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Amory et al (2011) Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J.Androl. 32 111. PMID: 20705791.
Hogarth et al (2011) Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol.Reprod. 84 957. PMID: 21209416.
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Keywords: WIN 18446, supplier, WIN18446, spermatogenesis, inhibitors, aldehyde, dehydrogenases, ALDH1a2