WIN 18446

Cat. No. 4736

WIN 18446 C12H20Cl4N2O2 [1477-57-2]

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Chemical Name: N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)

Biological Activity

Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC50 = 0.3 μM). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.

Technical Data

M.Wt:
366.11
Formula:
C12H20Cl4N2O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Storage:
Store at +4°C
CAS No:
1477-57-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Amory et al (2011) Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J.Androl. 32 111. PMID: 20705791.

Hogarth et al (2011) Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol.Reprod. 84 957. PMID: 21209416.

If you know of a relevant citation for this product please let us know.

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Keywords: WIN 18446, supplier, WIN18446, spermatogenesis, inhibitors, aldehyde, dehydrogenases, ALDH1a2

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