R&D Systems Inc. Tocris Bioscience Boston Biochem

WIN 18446

Cat. No. 4736

WIN 18446 C12H20Cl4N2O2 [1477-57-2]

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Chemical Name: N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)

Biological Activity

Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC50 = 0.3 μM). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.

Technical Data

M.Wt:
366.11
Formula:
C12H20Cl4N2O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Storage:
Store at +4°C
CAS No:
1477-57-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Amory et al (2011) Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J.Androl. 32 111. PMID: 20705791.

Hogarth et al (2011) Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol.Reprod. 84 957. PMID: 21209416.

If you know of a relevant citation for this product please let us know.

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Keywords: WIN 18446, supplier, WIN18446, spermatogenesis, inhibitors, aldehyde, dehydrogenases, ALDH1a2

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