Cat. No. 1521
Chemical Name: (2R*,4S*)-4-(1H-Tetrazol-5-ylmethyl)-2-piperidinecarboxylic acid
Biological ActivityCompetitive NMDA receptor antagonist (IC50 = 7 nM) that displays no affinity for AMPA or kainate receptors at a concentration of 10 μM. Inhibits NMDA-induced neuronal degeneration and protects from NMDA-induced convulsions in neonatal rats.
Licensing InformationSold with the permission of Eli Lilly and Company
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Schoepp et al (1990) Pharmacological characterization of LY233053: a structurally novel tetrazole-substituted competitive N-methyl-D-aspartic acid antagonist with a short duration of action. J.Pharmacol.Exp.Ther. 255 1301. PMID: 2148188.
Madden et al (1992) Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia. J.Neurosurg. 76 106. PMID: 1727148.
Madden et al (1993) Delayed therapy of experimental ischemia with competitive N-methyl-D-aspartate antagonists in rabbits. Stroke 24 1068. PMID: 8322381.
If you know of a relevant citation for this product please let us know.
Keywords: LY 233053, supplier, Competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, LY233053
Find multiple products by catalog number
New Products in this Area
Positive allosteric modulator of AMPACMPDA
Positive allosteric modulator of GluA2 receptors
Win a Kindle
June 3 - 5, 2013
Booth Number: C54