R&D Systems Inc. Tocris Bioscience Boston Biochem

3-Deazaneplanocin A hydrochloride

Cat. No. 4703

3-Deazaneplanocin A hydrochloride C12H14N4O3.HCl [120964-45-6]

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Alternative Names: DZNep, NSC 617989

Chemical Name: (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride

Biological Activity

Histone methyltransferase inhibitor; decreases global DNA methylation. Blocks EZH2 activity and trimethylation of lysine 27 on histone H3 in vitro. Induces apoptotic cell death in cancer cells and inhibits s-adenosylhomocysteine (SAH) hydrolase. Enhances Oct4 expression in chemically induced pluripotent stem cells (CiPSCs).

Technical Data

M.Wt:
298.73
Formula:
C12H14N4O3.HCl
Solubility:
Soluble to 10 mM in water
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
120964-45-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Tseng et al (1989) Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities. J.Med.Chem. 32 1442. PMID: 2544721.

Tan et al (2007) Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 21 1050. PMID: 17437993.

Miranda et al (2009) DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol.Cancer Ther. 8 1579. PMID: 19509260.

Hou et al (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341 651. PMID: 23868920.

If you know of a relevant citation for this product please let us know.

Keywords: 3-Deazaneplanocin A hydrochloride, supplier, 3-DeazaneplanocinA, NSC617989, Histone, methylation, inhibitors, EZH2, trimethylation, apoptosis, s-adenosylhomocysteine, hydrolase, SAHH, CiPSCs, stem, cells, reprogramming, induced, pluripotent, pluripotency

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