3-Deazaneplanocin A hydrochloride
Cat. No. 4703
Alternative Names: DZNep, NSC 617989
Chemical Name: (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,
Biological ActivityHistone methyltransferase inhibitor; decreases global DNA methylation. Blocks EZH2 activity and trimethylation of lysine 27 on histone H3 in vitro. Induces apoptotic cell death in cancer cells and inhibits s-adenosylhomocysteine (SAH) hydrolase. Enhances Oct 4 expression in chemically induced pluripotent stem cells (CiPSCs).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Tseng et al (1989) Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities. J.Med.Chem. 32 1442. PMID: 2544721.
Tan et al (2007) Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 21 1050. PMID: 17437993.
Miranda et al (2009) DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol.Cancer Ther. 8 1579. PMID: 19509260.
Hou et al (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341 651. PMID: 23868920.
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Keywords: 3-Deazaneplanocin A hydrochloride, supplier, 3-DeazaneplanocinA, NSC617989, Histone, methylation, inhibitors, EZH2, trimethylation, apoptosis, s-adenosylhomocysteine, hydrolase, SAHH, CiPSCs, stem, cells, reprogramming, induced, pluripotent, pluripotency
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