R&D Systems Inc. Tocris Bioscience Boston Biochem

NSC 74859

Cat. No. 4655

NSC 74859 C16H15NO7S [501919-59-1]

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Alternative Name: S3I-201

Chemical Name: 2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid

Biological Activity

Selectively inhibits STAT3 DNA-binding activity in vitro (IC50 values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). Blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo.

Technical Data

M.Wt:
365.36
Formula:
C16H15NO7S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
501919-59-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Siddiquee et al (2007) Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 104 7391. PMID: 17463090.

Lin et al (2009) The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 28 961. PMID: 19137011.

If you know of a relevant citation for this product please let us know.

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Keywords: NSC 74859, supplier, NSC74859, STAT3, inhibitors, DNA-binding, apoptosis

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