Cat. No. 4655
Alternative Name: S3I-201
Chemical Name: 2-Hydroxy-4-[[2-[[(4-methylphenyl)s
Biological ActivitySelectively inhibits STAT3 DNA-binding activity in vitro (IC50 values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). Blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Siddiquee et al (2007) Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 104 7391. PMID: 17463090.
Lin et al (2009) The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 28 961. PMID: 19137011.
If you know of a relevant citation for this product please let us know.
Keywords: NSC 74859, supplier, NSC74859, STAT3, inhibitors, DNA-binding, apoptosis
Find multiple products by catalog number
New Products in this Area
Highly potent and selective HIF-1α inhibitorNK 252
Nrf2 activatorCDDO Im
Nrf2 signaling activatorVerteporfin
YAP inhibitor; disrupts YAP-TEAD interactionsTC-S 7009
High affinity and selective HIF-2α inhibitor
September 5 - 8, 2015