Cat. No. 4655
Alternative Name: S3I-201
Chemical Name: 2-Hydroxy-4-[[2-[[(4-methylphenyl)s
Biological ActivitySelectively inhibits STAT3 DNA-binding activity in vitro (IC50 values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). Blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Siddiquee et al (2007) Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 104 7391. PMID: 17463090.
Lin et al (2009) The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 28 961. PMID: 19137011.
If you know of a relevant citation for this product please let us know.
Keywords: NSC 74859, supplier, NSC74859, STAT3, inhibitors, DNA-binding, apoptosis
Find multiple products by catalog number
New Products in this Area
Nrf2 activatorHLM 006474
E2F transcription factor inhibitorCCG 203971
Inhibits the MRTF/SRF gene transcription pathway; antifibrotic agentBRD 7552
PDX1 transcription factor inducer; increases insulin expressionRo 5-3335
Core binding factor inhibitor; attenuates hematopoiesis
December 16 - 18, 2014
Booth Number: 12