R&D Systems Inc. Tocris Bioscience Boston Biochem

SC 79

Cat. No. 4635

SC 79 C17H17ClN2O5 [305834-79-1]

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Chemical Name: 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester

Biological Activity

Activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.

Technical Data

M.Wt:
364.78
Formula:
C17H17ClN2O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
305834-79-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Jo et al (2012) Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc.Natl.Acad.Sci.USA 109 10581. PMID: 22689977.

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View Related Products by Target

Keywords: SC 79, supplier, SC79, Akt, protein, kinase, B, PKB, activators, activates, brain, penetrant

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