R&D Systems Inc. Tocris Bioscience Boston Biochem

GSK2578215A

Cat. No. 4629

GSK2578215A C24H18FN3O2 [1285515-21-0]

Price and Availability

For GSK2578215A pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinylbenzamide

Biological Activity

Potent leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values are 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Displays selectivity for LRRK2 against a panel of 460 other kinases. Blocks Ser910 and Ser935 phosphorylation in vitro and in peripheral tissues in vivo. Brain penetrant.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M.Wt:
399.42
Formula:
C24H18FN3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
1285515-21-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Reith et al (2012) GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substituent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg.Med.Chem.Lett. 22 5625. PMID: 22863203.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: GSK2578215A, supplier, leucine, rich, repeat, kinase, 2, LRRK2, inhibitors, inhibits, in, vivo, potent, selective, brain, penetrant, BBB, permeable, parkinsons, parkinson's

Quick Order

Find multiple products by catalog number

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 400 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Research Guide

Highlights over 250 products for neurodegeneration research. Request a copy or view PDF today.

divider line

Parkinson's disease: Neurobiology and Therapeutic Strategies

Written by Anthony H.V. Schapira

Parkinson's Poster

Updated in 2014 - this poster summarizes the neurobiology of Parkinson's disease (PD), including new genetic insight, neurotransmitter pathways, and the role of aberrant α-synuclein metabolism in PD pathogenesis.

divider line

New Product Guide

NPG

Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area

XL 413 hydrochloride

Potent and selective Cdc7 inhibitor

C16

PKR inhibitor

Rp-8-pCPT-cGMPS sodium

PKG inhibitor

TC-S 7004

Potent and selective DYRK1A/B inhibitor

TAK 960 hydrochloride

Potent and selective PLK1 inhibitor

A12B4C3

Potent and selective polynucleotide kinase/phosphatase (PKNP) inhibitor

BMS 345541

Selective allosteric inhibitor of IKK; anti-inflammatory

WH-4-023

Potent and selective Lck and Src inhibitor; also inhibits SIK

TC-S 7006

Potent and selective Tpl2 (Cot; MAP3K8) inhibitor

OXA 06 dihydrochloride

Potent ROCK inhibitor

PCI 29732

Potent BTK inhibitor

Mps1-IN-1 dihydrochloride

Selective monopolar spindle 1 (Mps1) kinase inhibitor

CKI 7 dihydrochloride

CK1 inhibitor

T 5601640

Selective LIMK2 inhibitor; antitumor

3PO

PFKFB3 inhibitor; antiangiogenic

CHR 6494 trifluoroacetate

Potent and selective haspin kinase inhibitor

UNC 3230

Potent and selective PIP5K1C inhibitor; antinociceptive

trans-ISRIB

Integrated stress response (ISR) inhibitor

BMS 509744

Potent and selective ITK inhibitor

WZ 4003

Potent and selective NUAK1/2 inhibitor

TC-S 7010

Potent and selective Aurora kinase A inhibitor

Bryostatin 2

Protein kinase C activator

Sign-up for new product e-alerts
divider line

Bio-Techne Events

EMBO 2015

The 6th EMBO Meeting 2015

September 5 - 8, 2015

Birmingham, UK