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GW 6471

Cat. No. 4618

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Chemical Name: N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide

Biological Activity

PPARα antagonist (IC₅₀ = 0.24 μM). Enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.

Licensing Information

Sold with the permission of GlaxoSmithKline.

Technical Data

M.Wt:

619.67

Formula:

C₃₅H₃₆F₃N₃O₄

Solubility:

Soluble to 75 mM in DMSO

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

880635-03-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Xu et al (2002) Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα. Nature 415 813. PMID: 11845213.

Muller et al (2009) An innovative method to study target protein-drug interactions by mass spectrometry. J.Med.Chem. 52 2875. PMID: 19379014.

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Keywords: GW 6471, supplier, GW6471, PPAR, PPARa, PPARalpha, PPARα, peroxisome, proliferator-activated, receptor, alpha, antagonists, GlaxoSmithKline, gsk