R&D Systems Inc. Tocris Bioscience Boston Biochem

Digoxin

Cat. No. 4583

Digoxin C41H64O14 [20830-75-5]

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Chemical Name: 4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one

Biological Activity

Inhibits membrane-bound α-subunits of the Na+/K+ ATPase pump in myocytes. Increases RGS2 protein levels in primary vascular smooth muscle cells through an Na+/K+ ATPase pump-dependent mechanism.

Technical Data

M.Wt:
780.94
Formula:
C41H64O14
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
20830-75-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Gheorghiade et al (2004) Digoxin in the management of cardiovascular disorders. Circulation 109 2959. PMID: 15210613.

Buckalew (2005) Endogenous digitalis-like factors. An historical overview. Front.Biosci. 10 2325. PMID: 15970498.

Sjogren et al (2012) Cardiotonic steroids stabilize regulator of g protein signaling 2 protein levels. Mol.Pharmacol. 82 500. PMID: 22695717.

If you know of a relevant citation for this product please let us know.

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Keywords: Digoxin, supplier, cardiac, glycoside, digitalis, sodium, potassium, ATP, Na+, K+, ATPase, pump

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