Cat. No. 4583
Chemical Name: 4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-
Biological ActivityInhibits membrane-bound α-subunits of the Na+/K+ ATPase pump in myocytes. Increases RGS2 protein levels in primary vascular smooth muscle cells through an Na+/K+ ATPase pump-dependent mechanism.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Gheorghiade et al (2004) Digoxin in the management of cardiovascular disorders. Circulation 109 2959. PMID: 15210613.
Buckalew (2005) Endogenous digitalis-like factors. An historical overview. Front.Biosci. 10 2325. PMID: 15970498.
Sjogren et al (2012) Cardiotonic steroids stabilize regulator of g protein signaling 2 protein levels. Mol.Pharmacol. 82 500. PMID: 22695717.
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Keywords: Digoxin, supplier, cardiac, glycoside, digitalis, sodium, potassium, ATP, Na+, K+, ATPase, pump