Digoxin

Cat. No. 4583

Digoxin C41H64O14 [20830-75-5]

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Chemical Name: 4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one

Biological Activity

Inhibits membrane-bound α-subunits of the Na+/K+ ATPase pump in myocytes. Increases RGS2 protein levels in primary vascular smooth muscle cells through an Na+/K+ ATPase pump-dependent mechanism.

Technical Data

M.Wt:
780.94
Formula:
C41H64O14
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
20830-75-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Gheorghiade et al (2004) Digoxin in the management of cardiovascular disorders. Circulation 109 2959. PMID: 15210613.

Buckalew (2005) Endogenous digitalis-like factors. An historical overview. Front.Biosci. 10 2325. PMID: 15970498.

Sjogren et al (2012) Cardiotonic steroids stabilize regulator of g protein signaling 2 protein levels. Mol.Pharmacol. 82 500. PMID: 22695717.

If you know of a relevant citation for this product please let us know.

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Keywords: Digoxin, supplier, cardiac, glycoside, digitalis, sodium, potassium, ATP, Na+, K+, ATPase, pump

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