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DIDSCat. No. 4523 |
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Chemical Name: 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt |
Biological Activity
ClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM).Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
References
Riquelme and Parra et al (1999) Regulation of human placental chloride channel by arachidonic acid and other cis unsaturated fatty acids. Am.J.Obstet.Gynecol. 180 469. PMID: 9988821.
Wulff (2008) New light on the "old" chloride channel blocker DIDS. ACS Chem.Biol. 3 399. PMID: 18642798.
Ishida et al (2009) DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange. Nucleic Acids Res. 37 3367. PMID: 19336413.
Zhang et al (2012) Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives. Mol.Pharmacol. 81 689. PMID: 22328719.
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Keywords: DIDS, supplier, chloride, channels, ClC-Ka, blockers, trpm4, trpc4, transient, receptor, potential, vanilloid, receptors, trpv1, rad51, homologous, recombination, dna, damage, repair, double, strand, breaks, 4,4-Diisothiocyanato-2,2-stilbenedisulfonic
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