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ML 213

Cat. No. 4519

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Chemical Name: N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide

Biological Activity

Selective K_V7.2 (KCNQ2) and K_V7.4 (KCNQ4) channel opener (EC₅₀ values are 230 and 510 nM for K_V7.2 and K_V7.4 respectively). Displays > 80-fold selectivity against K_V7.1, K_V7.3 and K_V7.5 in a thallium-based fluorescence assay.

Technical Data

M.Wt:

257.37

Formula:

C₁₇H₂₃NO

Solubility:

Soluble to 50 mM in DMSO and to 50 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

489402-47-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Yu et al (2011) Discovery, synthesis, and structure activity relationship of a series of N-aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener. ACS Chem.Neurosci. 2 572. PMID: 22125664.

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