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JW 55Cat. No. 4514 |
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Chemical Name: N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide |
Biological Activity
Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.Certificate of Analysis / Safety Data Sheet
References
Waaler et al (2012) A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 72 2822. PMID: 22440753.
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Keywords: JW 55, supplier, JW55, wnt, signaling, inhibitors, tankyrase, tnks1/2, tnks1, tnks2, beta-catenin, β-catenin, b-catenin
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