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DMFCat. No. 4512 |
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Alternative Name: Dimethyl fumarate Chemical Name: 2(E)-Butenedioic acid 1,4-dimethyl ester |
Biological Activity
Nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available.Certificate of Analysis / Safety Data Sheet
References
Linker et al (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134 678. PMID: 21354971.
Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274. PMID: 22267202.
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Keywords: DMF, supplier, dimethyl, fumarate, nuclear, factor, erythroid, derived, like, 2, Nrf2, pathway, activators, antioxidants, cytoprotective, neuroprotective, experimental, autoimmune, encephalomyelitis, EAE, myelin
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