R&D Systems Inc. Tocris Bioscience Boston Biochem

ICG 001

Cat. No. 4505

ICG 001 C33H32N4O4 [847591-62-2]

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Chemical Name: (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

Biological Activity

Inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.

Technical Data

M.Wt:
548.63
Formula:
C33H32N4O4
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
847591-62-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Emami et al (2004) A small molecule inhibitor of β-catenin/CREB-binding protein transcription. Proc.Natl.Acad.Sci.USA 101 12682. PMID: 15314234.

De Sousa et al (2011) Targeting wnt signaling in colon cancer stem cells. Clin.Cancer Res. 17 647. PMID: 21159886.

Zhou et al (2012) Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). J.Biol.Chem. 287 7026. PMID: 22241478.

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Keywords: ICG 001, supplier, ICG001, inhibits, inhibitors, TCF, t, cell, factors, b-catenin, beta-catenin, β-catenin, signaling, signalling, selectively

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