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DIM

Cat. No. 4502

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Alternative Name: 3,3-Diindolylmethane

Chemical Name: 3,3'-Methylenediindole

Biological Activity

Activator of Chk2 that causes G₂/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.

Technical Data

M.Wt:

246.31

Formula:

C₁₇H₁₄N₂

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

1968-05-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Kandala & Srivastava (2010) Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G₂/M cell cycle arrest in human ovarian cancer cells. Mol.Pharmacol. 78 297. PMID: 20444961.

Kandala et al (2012) Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J.Pharmacol.Exp.Ther. 341 24. PMID: 22205686.

Shorey et al (2012) 3,3'-diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One. 7 e34975. PMID: 22514694.

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