Cat. No. 4502
Alternative Name: 3,3-Diindolylmethane
Chemical Name: 3,3'-Methylenediindole
Biological ActivityActivator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Kandala & Srivastava (2010) Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Mol.Pharmacol. 78 297. PMID: 20444961.
Kandala et al (2012) Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J.Pharmacol.Exp.Ther. 341 24. PMID: 22205686.
Shorey et al (2012) 3,3'-diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One. 7 e34975. PMID: 22514694.
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Keywords: DIM, supplier, Chk2, checkpoint, kinase, 2, activators, antiproliferatives, anticancer, chemotherapeutics, epidermal, growth, factor, receptors, EGFR, inhibitors, inhibits, pro-apoptotic, apoptosis, inducers, 3,3-diindolylmethane
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