Cat. No. 4491
Chemical Name: 5-(4-Bromophenyl)-3-(1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl)-4,5-dihydro-g-oxo-1H-pyrazole-1-butanoic acid
Biological ActivityNoncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50 values are 2.7, 8.5, 121, 153, 198 and 206 μM respectively). Reduces frequency of channel opening.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Acker et al (2011) Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Mol.Pharmacol. 80 782. PMID: 21807990.
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Keywords: DQP 1105, supplier, DQP1105, supplier, NMDAD, NMDAD, Glu2NC, Glu2NC, antagonists, selective, noncompetitive, inhibitors, inhibits
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