Home » Pharmacology » Ion Channels » Potassium Channels » Voltage-gated Potassium (K_V) Channels » NS 3623

NS 3623

Cat. No. 4462

Price and Availability

For NS 3623 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea

Biological Activity

Human ether-a-go-go (hERG) K_V11.1 potassium channel activator. Activates the I_Kr current and displays antiarrhythmic activity. Exhibits potential dual mode of action at the hERG inhibitory site; may also act as a partial blocker of K_V11.1 (hERG) channels. Displays selectivity over the key cardiac potassium ion channels, K_V7.1 (KCNQ1), K_V1.5, and K_V4.3. Suitable for both in vitro and in vivo use.

Technical Data

M.Wt:

427.18

Formula:

C₁₅H₁₀BrF₃N₆O

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

343630-41-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Hansen et al (2006) Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]. Mol.Pharmacol. 70 1319. PMID: 16825484.

Hansen et al (2007) Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart. J.Pharmacol.Exp.Ther. 321 996. PMID: 17325228.

George (2009) Restoring repolarization in LQT3. Heart Rhythm. 6 107. PMID: 19121809 .

If you know of a relevant citation for this product please let us know.