Cat. No. 4462
Chemical Name: N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea
Biological ActivityHuman ether-a-go-go (hERG) KV11.1 potassium channel activator. Activates the IKr current and displays antiarrhythmic activity. Exhibits potential dual mode of action at the hERG inhibitory site; may also act as a partial blocker of KV11.1 (hERG) channels. Displays selectivity over the key cardiac potassium ion channels, KV7.1 (KCNQ1), KV1.5, and KV4.3. Suitable for both in vitro and in vivo use.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Hansen et al (2006) Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]. Mol.Pharmacol. 70 1319. PMID: 16825484.
Hansen et al (2007) Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart. J.Pharmacol.Exp.Ther. 321 996. PMID: 17325228.
George (2009) Restoring repolarization in LQT3. Heart Rhythm. 6 107. PMID: 19121809 .
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Keywords: NS 3623, supplier, hERG, activators, cardiac, ether-a-go-go, IKr, Kv11.1, potassium, channels, voltage-gated, Kv, anti-arrhythmic, NS3623
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