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Amitriptyline hydrochloride

Cat. No. 4456

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Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride

Biological Activity

Inhibitor of serotonin and noradrenalin uptake; also activates α_2A-adrenoceptors and antagonizes 5-HT₂ receptors. Displays antinociceptive activity. Tricyclic antidepressant (TCA).

Technical Data

M.Wt:

313.86

Formula:

C₂₀H₂₃N.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at RT

CAS No:

549-18-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Merck Index 12 85.

Sanchez and Hyttel (1999) Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell.Mol.Neurobiol. 19 467. PMID: 10379421.

Ghelardini et al (2000) Antinociception induced by amitriptyline and imipramine is mediated by α_2A-adrenoceptors. Jpn.J.Pharmacol. 82 130. PMID: 10877531.

Sawynok et al (2001) Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J.Psychiatry Neurosci. 26 21. PMID: 11212590.

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Keywords: Amitriptyline hydrochloride, supplier, serotonin, serotonergics, 5-HT, noradrenalin, noradrenaline, net, sert, reuptake, inhibitors, inhibits, tca, tricyclic, antidepressants