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Captopril

Cat. No. 4455

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Chemical Name: 1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-L-proline

Biological Activity

Angiotensin-converting enzyme (ACE) inhibitor (IC₅₀ = 0.022 μM). Also displays reversible, competitive inhibition of leukotriene A₄ (LTA₄) hydrolase.

Technical Data

M.Wt:

217.29

Formula:

C₉H₁₅NO₃

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

62571-86-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Orning et al (1991) Inhibition of leukotriene A₄ hydrolase/aminopeptidase by captopril. J.Biol.Chem. 266 16507. PMID: 1885582.

Zhang et al (1996) Effects of early captopril treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY). Clin.Exp.Hypertens. 18 201. PMID: 8869001.

Fujita and Yoshikawa (1999) LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology. 44 123. PMID: 10604535.

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Aminopeptidase Angiotensin-Converting Enzyme Hydrolases

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Keywords: Captopril, supplier, ACE, inhibitors, angiotensin-converting, enzyme, antihypertensives, LTA4, reversible, inhibits, peptidyl, dipeptidase, A, carboxycathepsin