Cat. No. 4439
Chemical Name: N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
Biological ActivityNeurogenic agent. Mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Schneider et al (2008) Small-molecule activation of neuronal cell fate. Nat.Chem.Biol 4 408. PMID: 18552832.
Dioum et al (2011) A small molecule differentiation inducer increases insulin production by pancreatic β cells. Proc.Natl.Acad.Sci.U.S.A. 108 20713. PMID: 22143803.
Zhang et al (2011) Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. Differentiation 81 233. PMID: 21419563.
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Keywords: ISX 9, supplier, ISX9, isoxazoles, neurogenic, neuronal, differentiation, neuroD1, CaMKII, MEF2, neurogenesis
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