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A 1070722

Cat. No. 4431

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Chemical Name: 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea

Biological Activity

Potent glycogen synthase kinase-3 (GSK-3) inhibitor (K_i = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.

Technical Data

M.Wt:

362.31

Formula:

C₁₇H₁₃F₃N₄O₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

1384424-80-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Bakker et al (2011) A-1070722, a potent, selective, and centrally active glycogen synthase kinase-3 (GSK-3) inhibitor for the treatment of psychiatric and neurodegenerative disorders. Society for Neuroscience (Abstract) 568.

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Keywords: A 1070722, supplier, A1070722, glycogen, synthase, kinases, 3, inhibits, inhibitors, potent, selective, brain, penetrant, neuroprotective, tau, phosphorylation, beta, b, amyloid

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