R&D Systems Inc. Tocris Bioscience Boston Biochem

SC 66

Cat. No. 4398

SC 66 C18H16N2O [871361-88-5]

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Chemical Name: (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone

Biological Activity

Allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.

Technical Data

M.Wt:
276.33
Formula:
C18H16N2O
Solubility:
Soluble to 75 mM in DMSO and to 75 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
871361-88-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Jo et al (2011) Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc.Natl.Acad.Sci.USA 108 6486. PMID: 21464312.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: SC 66, supplier, SC66, akt, pkb, protein, kinase, b, inhibitors, inhibits, allosteric, dual, activity, inhibitory

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