Cat. No. 4396
Chemical Name: 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone
Biological ActivityInduces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. Also inhibits the growth of spontaneous malignant breast tumors in mice. Displays little effect on normal cells. Rapidly depletes androgen receptor expression in human prostate cancer cells via a ROS-dependent, proteasome-mediated mechanism.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Raj et al (2011) Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 475 231. PMID: 21753854.
Golovine et al (2012) Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells. Prostate [Epub ahead of print]. PMID: 22592999.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Piperlongumine, supplier, antitumor, selectively, cytotoxic, increases, induces, ros, reactive, oxygen, species, cancer, cells, piperlongumine, supplier, androgen, receptor, p53, proapoptotic
Find multiple products by catalog number
New Products in this Area
Mcl-1 inhibitor; proapoptoticBAM 7
Selective Bax activator; induces Bax-mediated apoptosisMelphalan
DNA alkylating agent; cytotoxic and antineoplastic
Win a Kindle
May 21 - 24, 2013
Booth Number: 32