Home » Pharmacology » Ion Channels » Potassium Channels » Voltage-gated Potassium (K_V) Channels » Psora 4

Psora 4

Cat. No. 4367

Price and Availability

For Psora 4 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one

Biological Activity

Potent K_V1.3 channel blocker (EC₅₀ = 3 nM). Preferentially binds the C-type inactivated state of the channel, similar to the activity of CP 339818 (Cat. No. 1399). Displays 17- to 70-fold selectivity over closely-related K_V1 channels (K_V1, K_V2, K_V4 and K_V7); exhibits activity at K_V1.5 (IC₅₀ = 7.7 nM). Suppresses proliferation of human and rat myelin-specific effector memory T cells (EC₅₀ values are 25 and 60 nM respectively).

Technical Data

M.Wt:

334.37

Formula:

C₂₁H₁₈O₄

Solubility:

Soluble to 50 mM in DMSO and to 10 mM in ethanol

Purity:

>99 %

Storage:

Store at -20°C

CAS No:

724709-68-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Vennekamp et al (2004) Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol.Pharmacol. 65 1364. PMID: 15155830.

Schmitz et al (2005) Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol.Pharmacol. 68 1254. PMID: 16099841.

Li et al (2006) Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca²⁺-dependent mechanism. Am.J.Physiol.Cell Physiol. 290 C345. PMID: 16403947.

If you know of a relevant citation for this product please let us know.