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Ro 01-6128

Cat. No. 4348

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Chemical Name: (Diphenylacetyl)-carbamic acid ethy ester

Biological Activity

Positive allosteric modulator of mGlu₁ receptors. Potentiates glutamate-induced calcium release (EC₅₀ = 104.2 nM at rat mGluR1a).

Technical Data

M.Wt:

283.32

Formula:

C₁₇H₁₇NO₃

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

302841-86-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Knoflach et al (2001) Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc.Natl.Acad.Sci.USA 98 13402. PMID: 11606768.

Hemstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616. PMID: 16645124.

Brock et al (2007) Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement. J.Biol.Chem. 282 33000. PMID: 17855348.

If you know of a relevant citation for this product please let us know.

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Keywords: Ro 01-6128, supplier, Ro01-6128, metabotropic, glutamate, mglu1, mglur1, pam, positive, allosteric, modulators, potentiators

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