Cat. No. 4348
Chemical Name: (Diphenylacetyl)-carbamic acid ethy ester
Biological ActivityPositive allosteric modulator of mGlu1 receptors. Potentiates glutamate-induced calcium release (EC50 = 104.2 nM at rat mGluR1a).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Knoflach et al (2001) Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc.Natl.Acad.Sci.USA 98 13402. PMID: 11606768.
Hemstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616. PMID: 16645124.
Brock et al (2007) Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement. J.Biol.Chem. 282 33000. PMID: 17855348.
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Keywords: Ro 01-6128, supplier, Ro01-6128, metabotropic, glutamate, mglu1, mglur1, pam, positive, allosteric, modulators, potentiators
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