Cat. No. 4342
Chemical Name: N-(1-Cyclohexyl-4-piperidinyl)-2-[h
Biological ActivityPotent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50 values are 6 nM and 15 nM for G9a and GLP, respectively). Potently blocks G9a/GLP methyltransferase activity in cells (IC50 = 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50 = 4.7 μM in MCF7 cells). Selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Liu et al (2011) Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J.Med.Chem. 54 6139. PMID: 21780790.
If you know of a relevant citation for this product please let us know.
Keywords: UNC 0646, supplier, UNC0646, epigenetics, SGC, G9a, GLP, histone, protein, lysine, methyltransferases, PKMTs, HMTs, potent, selective, inhibitors
Find multiple products by catalog number
New Products in this Area
N-acetyltransferase 10 (NAT10) inhibitorEPZ 004777
Highly potent DOT1L inhibitorOICR 9429
High affinity and selective WDR5 antagonistMM 102
WDR5/MLL interaction inhibitorUNC 2327
Allosteric inhibitor of PRMT3GSK 2194069
Potent human fatty acid synthase (hFAS) inhibitorFuramidine dihydrochloride
Selective PRMT1 inhibitor
October 17-21, 2015