Cat. No. 4342
Chemical Name: N-(1-Cyclohexyl-4-piperidinyl)-2-[h
Biological ActivityPotent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50 values are 6 nM and 15 nM for G9a and GLP, respectively). Potently blocks G9a/GLP methyltransferase activity in cells (IC50 = 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50 = 4.7 μM in MCF7 cells). Selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Liu et al (2011) Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J.Med.Chem. 54 6139. PMID: 21780790.
If you know of a relevant citation for this product please let us know.
Keywords: UNC 0646, supplier, UNC0646, epigenetics, SGC, G9a, GLP, histone, protein, lysine, methyltransferases, PKMTs, HMTs, potent, selective, inhibitors
Find multiple products by catalog number
New Products in this Area
Potent and selective EZH2/EZH1 histone lysine methyltransferase inhibitorGarcinol
PCAF/p300 HAT inhibitor; anticancer(S)-PFI 2 hydrochloride
Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)A 366
Potent and selective G9a/GLP histone lysine methyltransferase inhibitorSTF 118804
NAMPT inhibitorSGI 1027
DNA methyltransferase inhibitor
March 18 - 21, 2015
Göttingen University, Germany