UNC 0646

Cat. No. 4342

UNC 0646 C36H59N7O2 [1320288-17-2]

Price and Availability

For UNC 0646 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine

Biological Activity

Potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50 values are 6 nM and 15 nM for G9a and GLP, respectively). Potently blocks G9a/GLP methyltransferase activity in cells (IC50 = 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50 = 4.7 μM in MCF7 cells). Selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Liu et al (2011) Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J.Med.Chem. 54 6139. PMID: 21780790.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: UNC 0646, supplier, UNC0646, epigenetics, SGC, G9a, GLP, histone, protein, lysine, methyltransferases, PKMTs, HMTs, potent, selective, inhibitors, Lysine Methyltransferase Inhibitors

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide


Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Epigenetics Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown. Request copy or view PDF today.

divider line

New Products in this Area


FASN inhibitor


N-acetyltransferase 10 (NAT10) inhibitor

EPZ 004777

Highly potent DOT1L inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

One Day Symposium

Bio-Techne Symposium 2015

Stem Cells & Organoids as Models of Tissue Differentiation & Disease

January 12, 2016

London, UK