R&D Systems Inc. Tocris Bioscience Boston Biochem

HBX 41108

Cat. No. 4285

HBX 41108 C13H3ClN4O [924296-39-9]

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Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

Biological Activity

Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

Licensing Information

Sold for research use only under patent license from Hybrigenics S.A.

Technical Data

M.Wt:
266.64
Formula:
C13H3ClN4O
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
924296-39-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Colland et al (2009) Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol.Cancer Ther. 8 2286. PMID: 19671755.

Colombo et al (2010) Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem 5 552. PMID: 20186914.

If you know of a relevant citation for this product please let us know.

Keywords: HBX 41108, supplier, HBX41108, ubiquitin-specific, proteases, usp7, selective, inhibitors, proteasome, ubiquitin, deubiquitination, hausp, herpesvirus-associated

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Tocris Product News

Novel USP7 inhibitor

Tocris Bioscience licenses the novel USP7 inhibitor, HBX41108

Tocris is the exclusive supplier of HBX 41108 - a USP7 inhibitor licensed from Hybrigenics.