HBX 41108

Cat. No. 4285

HBX 41108 C13H3ClN4O [924296-39-9]

Price and Availability

For HBX 41108 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

Biological Activity

Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

Licensing Information

Sold for research use only under patent license from Hybrigenics S.A.

Technical Data

Soluble to 100 mM in DMSO and to 25 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet


Colland et al (2009) Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol.Cancer Ther. 8 2286. PMID: 19671755.

Colombo et al (2010) Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem 5 552. PMID: 20186914.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: HBX 41108, supplier, HBX41108, ubiquitin-specific, proteases, usp7, selective, inhibitors, proteasome, ubiquitin, deubiquitination, hausp, herpesvirus-associated, Tocris Bioscience, Deubiquitinating Enzyme Inhibitors

Quick Order

Find multiple products by catalog number

divider line

New Product Guide


Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area

VTP 27999 trifluoroacetate

Highly potent and selective renin inhibitor


Plasminogen activator inhibitor-1 (PAI-1) inhibitor


Potent and selective cathepsin K inhibitor

HFI 142

Insulin-regulated aminopeptidase (IRAP) inhibitor

SSM 3 trifluoroacetate

Potent furin inhibitor

Sign-up for new product e-alerts
divider line

Tocris Product News

Novel USP7 inhibitor

Tocris Bioscience licenses the novel USP7 inhibitor, HBX41108

Tocris is the exclusive supplier of HBX 41108 - a USP7 inhibitor licensed from Hybrigenics.