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HBX 41108

Cat. No. 4285

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Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

Biological Activity

Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC₅₀ = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC₅₀ = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

Licensing Information

Sold for research use only under patent license from Hybrigenics S.A.

Technical Data

M.Wt:

266.64

Formula:

C₁₃H₃ClN₄O

Solubility:

Soluble to 100 mM in DMSO and to 25 mM in ethanol

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

924296-39-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Colland et al (2009) Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol.Cancer Ther. 8 2286. PMID: 19671755.

Colombo et al (2010) Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem 5 552. PMID: 20186914.

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Keywords: HBX 41108, supplier, HBX41108, ubiquitin-specific, proteases, usp7, selective, inhibitors, proteasome, ubiquitin, deubiquitination, hausp, herpesvirus-associated