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[D-Trp⁸]-γ-MSH

Cat. No. 4272

[D-Trp8]-gamma-MSH Tyr-Val-Met-Gly-His-Phe-Arg-D-Trp-Asp-Arg-Phe-Gly

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Biological Activity

Selective melanocortin 3 (MC₃) receptor agonist (IC₅₀ values are 6.7, 340 and 600 nM for human MC₃, MC₅ and MC₄ receptors respectively). Displays anti-inflammatory efficacy.

Technical Data

M.Wt:

1570.79

Formula:

C₇₄H₉₉N₂₁O₁₆S

Sequence:

YVMGHFRWDRFG

(Modifications: Trp-8 = D-Trp)

Solubility:

Soluble to 1 mg/ml in water

Storage:

Store at -20°C

CAS No:

321351-81-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Grieco et al (2000) D-amino acid scan of γ-melanocyte-stimulating hormone: importance of Trp⁸ on human MC3 receptor selectivity. J.Med.Chem. 43 4998. PMID: 11150170.

Getting et al (2006) [D-Trp⁸]-γ-Melanocyte-stimulating-hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol.Pharmacol. 70 1850. PMID: 16959942.

Patel et al (2010) Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J. 24 4835. PMID: 20702773.

If you know of a relevant citation for this product please let us know.

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Keywords: [D-Trp8]-gamma-MSH, supplier, melanocortin, 3, receptors, MC3R, agonists, MC3, MC5, MC4, [D-Trp8]-gamma-MSH, [D-Trp8]-g-MSH, [D-Trp8]-γ-MSH

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