R&D Systems Inc. Tocris Bioscience Boston Biochem

A 887826

Cat. No. 4249

A 887826 C26H29ClN4O3 [1266212-81-0]

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Chemical Name: 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide

Biological Activity

Potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV1.8 channels compared to NaV1.2 and NaV1.7 channels respectively.

Technical Data

M.Wt:
480.99
Formula:
C26H29ClN4O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>97 %
Storage:
Store at RT
CAS No:
1266212-81-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Zhang et al (2010) A-887826 is a structurally novel, potent and voltage-dependent NaV1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. Neuropharmacology 59 201. PMID: 20566409.

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View Related Products by Target

Keywords: A 887826, supplier, A887826, sodium, channel, blocker, blocks, NaV1.8, voltage-dependent, ion, channels, antiallodynic

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