Cat. No. 4195
Chemical Name: 2-Amino-N-(3-octylphenyl)-3-(phosphonooxy)-propanamaide
Biological ActivitySphingosine-1-phosphate receptor antagonist; inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Davis et al (2005) Sphingosine-1-phosphate analogs as receptor antagonists. J.Biol.Chem. 280 9833. PMID: 15590668.
Aoki et al (2007) The suppressive effect of sphingosine-1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins α5β1 and αVβ3. J.Thromb.Haemost. 5 1292. PMID: 17403093.
Mihovilovic et al (2007) High-fat/cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. J.Lipid Res. 48 806. PMID: 17264352.
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Keywords: VPC 23019, supplier, VPC23019, sphingosine-1-phosphate, s1p1, s1p3, antagonists, s1p, sphingolipids
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