Cat. No. 4188
Chemical Name: 3-(Aminocarbonyl)-β-(3-cyclohexylpro
Biological ActivityPotent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Allan et al (2006) Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica 36 399. PMID: 16854779.
Fish et al (2007) Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J.Med.Chem. 50 3442. PMID: 17591762.
Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562. PMID: 18945617.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: UK 383367, supplier, pfizer, UK383367, procollagen, c, proteinase, BMP-1, bone, morphogenic, morphogenetic, proteins, inhibitors, Matrix Metalloprotease Inhibitors
Find multiple products by catalog number
New Products in this Area
Highly potent and selective renin inhibitorTiplaxtinin
Plasminogen activator inhibitor-1 (PAI-1) inhibitorBalicatib
Potent and selective cathepsin K inhibitorHFI 142
Insulin-regulated aminopeptidase (IRAP) inhibitorSSM 3 trifluoroacetate
Potent furin inhibitor(Z-LL)2 ketone
Putative inhibitor of signal peptide peptidasePR 619
Broad spectrum DUB inhibitor
December 12 - 16, 2015
San Diego, CA, CA