R&D Systems Inc. Tocris Bioscience Boston Biochem

UK 383367

Cat. No. 4188

UK 383367 C15H24N4O4 [348622-88-8]

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Chemical Name: 3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide

Biological Activity

Potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
324.38
Formula:
C15H24N4O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
348622-88-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Allan et al (2006) Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica 36 399. PMID: 16854779.

Fish et al (2007) Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J.Med.Chem. 50 3442. PMID: 17591762.

Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562. PMID: 18945617.

If you know of a relevant citation for this product please let us know.

Keywords: UK 383367, supplier, pfizer, UK383367, procollagen, c, proteinase, BMP-1, bone, morphogenic, morphogenetic, proteins, inhibitors

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