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Ro 3306

Cat. No. 4181

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Chemical Name: 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone

Biological Activity

ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (K_i values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively). Induces G₂/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML).

Technical Data

M.Wt:

351.45

Formula:

C₁₈H₁₃N₃OS₂

Solubility:

Soluble to 50 mM in DMSO

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

872573-93-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Vassilev et al (2006) Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc.Natl.Acad.Sci. 103 10660.

Kojima et al (2009) The CDK1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci. 100 1128. PMID: 19385969.

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