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Delavirdine mesylate

Cat. No. 4149

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Alternative Name: U 90152

Chemical Name: 1-[3-[(1-Methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-piperazine monomethanesulfonate

Biological Activity

Non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC₅₀ values are 0.26, 440 and >550 μM for HIV-1 reverse transcriptase, DNA polymerase α and DNA polymerase δ). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active.

Licensing Information

Sold for research purposes under agreement from Viiv.

Technical Data

M.Wt:

552.67

Formula:

C₂₂H₂₈N₆O₃S.CH₃SO₃H

Solubility:

Soluble to 75 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at RT

CAS No:

147221-93-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Dueweke et al (1993) U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob.Agents Chemother. 37 1127. PMID: 7685995.

Pagano and Chong (1995) In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavirdine (U-90152) with protease inhibitor U-75875 or interferon-alpha. J.Infect.Dis. 171 61. PMID: 7528253.

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Keywords: Delavirdine mesylate, supplier, reverse, transcriptase, inhibitors, polymerases, RNA/DNA, antivirals, antiretrovirals, HIV, non-nucleoside, NNRTI, HIV-1, U90152