Cat. No. 4138
Chemical Name: N-[2-[(4-Hydroxyphenyl)amino]-3-pyr
Biological ActivityAntimitotic agent, inhibits microtubule polymerization. Binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis. Exhibits antitumor activity. Also displays activity in cell lines resistant to vincristine, doxorubicin and cisplatin. Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Hande et al (2006) The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: results of a phase 1 study. Clin.Cancer Res. 12 2834. PMID: 16675578.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: ABT 751, supplier, ABT751, microtubule, antitumor, antimitotic, beta, tubulin, b-tubulin, blocks, cell, cycle, G2M, proapoptotic
Find multiple products by catalog number
New Products in this Area
Inhibitor of mitotic motor kinesin Eg5MPC 6827 hydrochloride
Inhibitor of microtubule polymerization; antimitotic and antitumorSB 743921 hydrochloride
Potent kinesin spindle protein (KSP) inhibitor
December 6 - 10, 2014
Booth Number: 515