ABT 751

Cat. No. 4138

ABT 751 C18H17N3O4S [141430-65-1]

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Chemical Name: N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide

Biological Activity

Antimitotic agent, inhibits microtubule polymerization. Binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis. Exhibits antitumor activity. Also displays activity in cell lines resistant to vincristine, doxorubicin and cisplatin. Orally bioavailable.

Technical Data

M.Wt:
371.41
Formula:
C18H17N3O4S
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
141430-65-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Hande et al (2006) The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: results of a phase 1 study. Clin.Cancer Res. 12 2834. PMID: 16675578.

If you know of a relevant citation for this product please let us know.

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Keywords: ABT 751, supplier, ABT751, microtubule, antitumor, antimitotic, beta, tubulin, b-tubulin, blocks, cell, cycle, G2M, proapoptotic, Tocris Bioscience, Microtubules

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