R&D Systems Inc. Tocris Bioscience Boston Biochem

ABT 751

Cat. No. 4138

ABT 751 C18H17N3O4S [141430-65-1]

Price and Availability

For ABT 751 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide

Biological Activity

Antimitotic agent, inhibits microtubule polymerization. Binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis. Exhibits antitumor activity. Also displays activity in cell lines resistant to vincristine, doxorubicin and cisplatin. Orally bioavailable.

Technical Data

M.Wt:
371.41
Formula:
C18H17N3O4S
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
141430-65-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Hande et al (2006) The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: results of a phase 1 study. Clin.Cancer Res. 12 2834. PMID: 16675578.

If you know of a relevant citation for this product please let us know.

Keywords: ABT 751, supplier, ABT751, microtubule, antitumor, antimitotic, beta, tubulin, b-tubulin, blocks, cell, cycle, G2M, proapoptotic

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Research Guide

Highlights over 250 products for neurodegeneration research. Request a copy or view PDF today.

divider line

New Product Guide

NPG

Highlights 150 new products added in the second half of 2014. View PDF today.

divider line

New Products in this Area

BRD 9876

ATP non-competitive kinesin Eg5 inhibitor

BTB1

Selective and ATP-competitive Kif18A inhibitor

Dimethylenastron

Inhibitor of mitotic motor kinesin Eg5

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.