R&D Systems Inc. Tocris Bioscience Boston Biochem

C3bot (154-182)

Cat. No. 4123

C3bot (154-182) Val-Ala-Lys-Gly-Ser-Lys-Ala-Gly-Tyr-Ile-Asp-Pro-Ile-Ser-Ala-Phe-Ala-Gly-Gln-Leu-Glu-Met-Leu-Leu-Pro-Arg-His-Ser-Thr

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Biological Activity

Transferase-deficient neurotrophic fragment of clostridial C3 protein. Promotes axonal and dendritic growth and branching of hippocampal neurons at submicromolar concentrations. Also promotes reinnervation of target tissues in organotypical hippocampal/entorhinal slice cultures. Reduces levels of active neuronal RhoA by a non-enzymatic mechanism. Enhances functional recovery and regeneration in a mouse model of spinal cord injury.

Technical Data

M.Wt:
3058.54
Formula:
C137H221N37O40S
Sequence:
VAKGSKAGYIDPISAFAGQLEMLLPRHST
Solubility:
Soluble to 5 mg/ml in water
Storage:
Store at -20°C
CAS No:
1246280-79-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Holtje et al (2009) A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation. FASEB J. 23 1115. PMID: 19047066.

Boato et al (2010) C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts. J.Cell Science 123 1652.

Just et al (2011) Therapeutic effects of Clostridium botulinum C3 exoenzyme. Naunyn-Schmied.Arch.Pharmacol. 383 247.

If you know of a relevant citation for this product please let us know.

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Keywords: C3bot (154-182), supplier, clostridium, clostridial, C3, protein, neurotrophic, axon, dendrite, outgrowth, transferase-deficient, peptide, fragment, spinal, cord, injury, injuries, c3, bot154-182

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